Sentence 4: Prokaryotic cells however have no true nucleus.
Which of the following options properly rewrites sentence 4?

A comma should be used to separate an interjection from the rest of the sentence. A semicolon should not be used in this sentence as they are used: (1) to join two or more independent clauses; (2) with transitional phrases and conjunctive adverbs; and (3) to separate groups that contain commas. The placement of the adverb \u201Chowever\u201D at the end of the sentence is grammatically incorrect.